Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis
Abstract Background Burkholderia pseudomallei is the causative agent of melioidosis, a tropical disease of humans with a variable and often fatal outcome.In murine models of infection, different strains exhibit varying degrees of virulence.In contrast, two related species, B.thailandensis and B.oklahomensis, are highly attenuated in mice.Our aim wa